Sub-Acute Sclerosing Panencephalitis at University Hospital of Constantine
نویسندگان
چکیده
Introduction Subacute sclerosing panencephalitis (SSPE) is a serious, late complication of measles, and the prognosis remains poor in absence effective treatment, underscoring role vaccination its prevention. Objectives We describe clinicobiological evolutionary profile 16 patients recruited from B chu de Constantine pediatric department. Patients methods Study of16 cases: epidemiological, clinical, EEG, biological profile. Results16 cases SSPE were collected, 75% male, 70% aged between 24 59 months, almost all had 98% within first months life, 93% not been vaccinated against occurred more than 50% 48 after received treatment (100% corticosteroids immunoglobulins), 87% antiepileptics 25% rituximab, course was characterized by stabilization: 27%, death: 33% deterioration:40% cases. Comments discussion rare occurring few years recovery measles Almost our measles. patients, median age at onset 4.5 This earlier recent studies reported older suggests early viral mutation or fragile immune system. unvaccinated measles; 40% died, 31% worsened (stage IV) 37% stabilized. Conclusion Given SSPE, best way to control this disease vaccinate target population
منابع مشابه
[Subacute sclerosing panencephalitis].
Subacute sclerosing panencephalitis is a slowly progressive neurodegenerative disorder occurring in childhood and adolescence and is characterised by dementia, ataxia, myoclonias and other neurological focal signs, with an invariably fatal outcome. The author reviews the subject, focussing on epidemiology, clinical features, measles virus behaviour, host immune reactions, measles prophylaxis an...
متن کاملSubacute sclerosing panencephalitis.
Introduction Subacute sclerosing panencephalitis (SSPE) is a rare disease which predominantly affects children of school age. The clinical features include an insidious afebrile onset with behavioural disturbance and progressive dementia sometimes associated with epilepsy. Later akinetic mutism and myoclonic jerks with pyramidal and extrapyramidal signs appear. Finally there is progressive deco...
متن کامل[Subacute sclerosing panencephalitis].
Subacute sclerosing panencephalitis (SSPE) is now considered to be caused by measles virus. There are four diagnostic criteria, namely the clinical picture, a characteristic EEG, serology of serum and CSF and brain histology. A register of cases in the U.K. has been kept since 1971, and up to September 1977, ninety-six patients have been reported. The male/female ratio is 2 : 1. The disease mos...
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ژورنال
عنوان ژورنال: International journal of medical science and clinical research studies
سال: 2023
ISSN: ['2767-8326', '2767-8342']
DOI: https://doi.org/10.47191/ijmscrs/v3-i7-06